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	Provedor de dados Genet. Mol. Biol. (1) Autor Guo,Changlei (1) Hu,Fudong (1) Liu,Hengdao (1) Wang,Yakun (1) Zhang,Shaoli (1) Palavra-chave Cardiovascular disease (1) Osteoprotegerin (1) Polymorphism (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2013 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Association between osteoprotegerin gene polymorphisms and cardiovascular disease in type 2 diabetic patients Genet. Mol. Biol. Guo,Changlei; Hu,Fudong; Zhang,Shaoli; Wang,Yakun; Liu,Hengdao. Osteoprotegerin (OPG) gene polymorphisms (T245G, T950C and G1181C) have been associated with osteoporosis and early predictors of cardiovascular disease. The aim of this study was to evaluate whether these polymorphisms contribute to cardiovascular disease (CVD) in type 2 diabetic patients. We performed a case-control study with 178 CVD subjects with diabetes and 312 diabetic patients without CVD to assess the impact of variants of the OPG gene on the risk of CVD. The OPG gene polymorphisms were analyzed by using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). There was no significant association between the T245G and G1181C polymorphisms and CVD in the additive genetic model (OR = 0.96, 95% CI 0.64-1.45, p = 0.79;... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cardiovascular disease; Osteoprotegerin; Polymorphism. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000200006 Registros recuperados: 1 Primeira ... 1 ... Última

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